Computational Study of Collective Cell Migration by Meshfree Method

  • Liqiang Lin
  • Jie Bai
  • Xiaowei Zeng University of Texas at San Antonio
Keywords: Cell-cell interaction; cell-substrate interaction; collective cell migration; meshfree method; numerical simulation


The collective cell migration behavior on a substrate was studied by using RKPM meshfree method. The cells were modeled as nematic liquid crystal with a hyperelastic cell nucleus. A coarse-grained potential force was proposed to model the cell-substrate and cell-cell interactions. Through this study, the pulling and pushing phenomenon during collective cell migration process was observed and it was found that the individual cell mobility significantly influenced the collective cell migratory behavior. More self-propelled cells are in the system along the same direction, the faster collective group migrates toward coordinated direction. It also showed that the mechanical stress in leader cell is higher than stress in follower cell.  


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