Molecular & Cellular Biomechanics http://tspsubmission.com/index.php/mcb <p style="text-align: justify;">Molecular &amp; Cellular Biomechanics is published by Tech Science Press. The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledges on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences.&nbsp;</p> en-US <div class="page" title="Page 1"> <div class="layoutArea"> <div class="column"> <div class="page" title="Page 2"> <div class="layoutArea"> <div class="column"> <p>Articles published by TSP are under an Open Access license, which means all articles published by TSP are accessible online free of charge and as free of technical and legal barriers to everyone. Published materials can be re-used if properly acknowledged and cited Open Access publication is supported by the authors' institutes or research funding agencies by payment of a comparatively low&nbsp;Article Processing Charge (APC)&nbsp;for accepted articles.</p> <p>TSP journals publish articles under the<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noopener">&nbsp;Creative Commons Attribution </a>License and&nbsp;are using the&nbsp;<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noopener">CC-BY license</a>.</p> </div> </div> </div> </div> </div> </div> mcb@techscience.com (MCB Editorial) mcb@techscience.com (MCB Editorial) Thu, 27 Feb 2020 06:31:12 +0800 OJS 3.2.1.4 http://blogs.law.harvard.edu/tech/rss 60 on the onset of cracks in arteries http://tspsubmission.com/index.php/mcb/article/view/7606 <p>We present a theoretical approach to study the onset of failure localization into cracks<br>in arterial wall. The arterial wall is a soft composite comprising hydrated ground matrix<br>of proteoglycans reinforced by spatially dispersed elastin and collagen ?bers. As any mate-<br>rial, the arterial tissue cannot accumulate and dissipate strain energy beyond a critical value.<br>This critical value is enforced in the constitutive theory via energy limiters. The limiters<br>automatically bound reachable stresses and allow examining the mathematical condition of<br>strong ellipticity. Loss of the strong ellipticity physically means inability of material to propa-<br>gate superimposed waves. The waves cannot propagate because material failure localizes into<br>cracks perpendicular to a possible wave direction. Thus, not only the onset of a crack can be<br>analyzed but also its direction.<br>We use the recently developed constitutive theories of the arterial wall including 8 and<br>16 structure tensors to account for the ?ber dispersion. We enhance these theories with<br>energy limiters. We examine the loss of strong ellipticity in uniaxial tension and pure shear in<br>circumferential and axial directions of the arterial wall. We ?nd that the vanishing longitudinal<br>wave speed predicts the appearance of cracks in the direction perpendicular to tension. We<br>also ?nd that the vanishing transverse wave speed predicts the appearance of cracks in the the<br>direction inclined (non-perpendicular) to tension. The latter result is counter-intuitive yet it<br>is supported by recent experimental observations.</p> Konstantin Volokh, Pullela Mythravaruni Copyright (c) 2020 Konstantin Volokh, Pullela Mythravaruni http://tspsubmission.com/index.php/mcb/article/view/7606 Thu, 27 Feb 2020 00:00:00 +0800 Kinematic and Dynamic Characteristics of Pulsating Flow in 180 Degree Tube http://tspsubmission.com/index.php/mcb/article/view/7817 <p>Kinematic and dynamic characteristics of pulsating flow in a model of human aortic arch are obtained by a computational analysis. Three-dimensional flow processes are summarized by pressure distributions on the symmetric plane together with velocity and pressure contours on a few cross sections for systolic acceleration and deceleration. Without considering the effects of aortic tapering and the carotid arteries, the development of tubular boundary layer with centrifugal forces and pulsation are also analyzed for flow separation and backflow during systolic deceleration.</p> Tin-Kan Hung, Ruei-Hung Kuo, Cheng-Hsien Chiang Copyright (c) 2020 Tin-Kan Hung, Ruei-Hung Kuo, Cheng-Hsien Chiang http://tspsubmission.com/index.php/mcb/article/view/7817 Thu, 27 Feb 2020 00:00:00 +0800 A A Study on the Finite Element Model for Head Injury in Facial Collision Accident http://tspsubmission.com/index.php/mcb/article/view/7534 <p><span lang="EN-US" style="margin: 0px; color: black; font-family: 'Times New Roman',serif; font-size: 11pt;">This paper aims at predicting and evaluating the biomechanical response of the facial impact on head injury in a crash accident. With the combination of CT/MRI medical imaging technique, the 50th percentile head biomechanical model with detailed cranio-facial structure is established. After which the validity of the model based on the classical experimental data from Nahum and Trosseille is verified. Based on the analysis of nine typical facial collision scenes, this work studies the propagation path of stress wave in the skull, then brain, von Mises stress and shear stress distribution are achieved. It is proved that facial structure can absorb a large amount of impact energy to protect the brain. The propagation path and distribution of stress wave in the skull and brain determine the mechanism of brain impact injury, which provides a theoretic basis for the diagnosis, treatment and protection of craniocerebral injury caused by facial impact.</span></p> Bin Yang, Hao Sun, Aiyuan Wang, Qun Wang Copyright (c) 2020 Bin Yang, Hao Sun, Aiyuan Wang, Qun Wang http://tspsubmission.com/index.php/mcb/article/view/7534 Thu, 27 Feb 2020 00:00:00 +0800 Multifrequency Microwave Imaging for Brain Stroke Detection http://tspsubmission.com/index.php/mcb/article/view/7165 <p>This paper describes the feasibility of the use of a multifrequency holographic microwave imaging (HMI) algorithm for brain stroke detection. A numerical system, including HMI data collection model and a realistic head model, was developed to demonstrate the proposed method for imaging of brain tissues. Various experiments were carried out to evaluate the performance of the proposed method. The multifrequency HMI was also compared with the previously developed single frequency HMI. Results suggest that the multifrequency HMI could clearly identify stroke with more correct information on location and size than the single frequency HMI.</p> LULU WANG Copyright (c) 2020 LULU WANG http://tspsubmission.com/index.php/mcb/article/view/7165 Wed, 26 Feb 2020 00:00:00 +0800