Torin 1-mTOR inhibitor enhances cellular proliferation in NT-1 tobacco suspension cell cultures

  • Grisel Fierros Fierros Romero Instituto Tecnológico y de Estudios Superiores de Monterrey
  • María Elena Mellado Rojas, DR Universidad Michoacana de San Nicolás de Hidalgo
  • Reynaldo C. Pless, Dr Instituto Politécnico Nacional
  • Juan Ignacio Valiente Banuet, Dr Instituto Tecnológico y de Estudios Superiores de Monterrey
  • Ashutosh Fierros Sharma, Dr Instituto Tecnológico y de Estudios Superiores de Monterrey
  • Elda María Beltrán Peña, Dr Universidad Michoacana de San Nicolás de Hidalgo
Keywords: Torin 1, TOR, S6K, proliferation, NT-1 tobacco cells

Abstract

Torin 1, is an ATP-competitive kinase inhibitor targeting rapamycin (TOR) which inhibits the signaling of TOR and S6K kinase in mammals and plants. During kinetics growth of tobacco cultures suspended in NT-1, Torin 1 inhibits the early growth and later enhanced the cellular proliferation during exponential growth by means of an increased expression of E2F1 and cyclin B.

Published
2019-08-07
Section
Articles